I had the same problem till I solved the problem. I've tried everything like downgrade to 4.4, changing microphone setting, repairing with sony pc companion. Nothing solved the problem so dont do that things. Here is the solution. Go to setting then call. Turn off microphone noise suspension and speaker enhance and slow talk. Then restart your phone.after 5 minutes do the factory reset with delete everything option. I mean tick the option which delete your internal memory. After that your phone is ok but dont chang any options in call setting. Don't turn off or on any setting in there like microphone noise or speaker enhance or slow talk. Leave those options what it is. Your phone is fine again
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Like I said it's a balance, there's rarely been a phone without a trade off. For most of the Nexus phones, the camera's were poor. I loved the Galaxy Nexus but the battery life was appalling. The Nexus 5 was great but mine had a little bit of light bleed from the corner of the screen. The Nexus 4 glass back shattered easily. The HTC One M7 had gaps in the construction (again I only noticed when I was looking) etc etc Out of all the phones I've listed, only the HTC Desire HD went back to the store a few days later, due to utterly abysmal battery life. My advice is to go and play with one in a shop and compare to others you may like and see how you like the look and feel of the device.
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